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  5. 26 High-Protein Casseroles That Are Perfect for Dinner

26 High-Protein Casseroles That Are Perfect for Dinner

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Danielle DeAngelis Reviewed by Dietitian Jessica Ball, M.S., RD September 16, 2022
Reviewed by Dietitian Jessica Ball, M.S., RD
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Philly Chicken Cheesesteak Casserole
Credit: Diana Chistruga

Looking for some dinner inspiration? Whip up one of these main dish casseroles for a filling and tasty meal. With at least 15 grams of protein per serving, these nutritious dinners can help support healthy digestion, healthy immune function and muscle growth. Recipes like our Cheesy Meatball Casserole and Philly Chicken Cheesesteak Casserole are comforting and nourishing choices for a delicious evening meal.

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Tater Tot Casserole with Beef, Corn & Zucchini

Skillet Beef, Corn & Zucchini Tater Tot Casserole
Credit: Jason Donnelly
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Casseroles can be for summer too! We packed this one with peak-season vegetables—corn, zucchini and tomatoes—then topped it with crispy tater tots and gooey melted cheese, making it a dinner winner.

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Cheesy Meatball Casserole

cheesy meatball casserole
Credit: Jen Causey
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This cheesy meatball casserole is a family favorite, with basil adding flavor to the meatballs and grated onion adding moisture. Melted mozzarella cheese tames the spice, but feel free to cut back or eliminate the crushed red pepper if you prefer a milder dish.

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Chicken Enchilada Skillet Casserole

Chicken Enchilada Skillet Casserole
Credit: Jacob Fox
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This simplified take on cheesy chicken enchiladas only requires one pan for cooking and eliminates the need to stuff and roll corn tortillas. Charring the veggies in a cast-iron skillet adds depth of flavor. Don't worry if you don't have one, because you can use any oven-safe skillet instead.

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Cabbage Roll Casserole

Cabbage Roll Casserole
Credit: Brie Passano
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This casserole has all the elements of cabbage rolls—ground beef, onion and rice cooked in tomato sauce—and skips the fuss of rolling. The cabbage is chopped instead and layered with the saucy filling, then topped with cheese, for a satisfying and easy casserole. Feel free to substitute other ground meats, such as turkey, for the ground beef—this recipe would also be great with a vegetarian meat substitute.

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Philly Chicken Cheesesteak Casserole

Philly Chicken Cheesesteak Casserole
Credit: Diana Chistruga
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This Philly chicken cheesesteak casserole tastes just like the classic sandwich version but in casserole form. We swapped out the beef for ground chicken and added pasta to bring this quick one-skillet dinner together.

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Tuna Casserole with Peas

Tuna Casserole with Peas
Credit: Leslie Grow | Tuna Casserole with Peas
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Maya Feller, M.S., RD, CDN, of Brooklyn-based Maya Feller Nutrition, has worked with many low-income families and is well-versed in the realities of putting food on the table that is healthy, tastes good, isn't time-prohibitive and is affordable. "A traditional tuna casserole provides both protein and carbohydrates to keep you full, and is kid-friendly and easy to make," she says about this tuna casserole recipe. (This recipe was part of a feature story, "The Real Cost of Healthy Food," in EatingWell magazine and has not been tested by our Test Kitchen.)

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Eggplant & Chickpea Baked Pasta

Eggplant & Chickpea Baked Pasta
Credit: Photography / Fred Hardy, Styling / Ruth Blackburn / Audrey Davis
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Turn leftover Eggplant & Chickpea Stew into a comforting vegetarian baked-pasta dish. We love the taste of mint with the other Mediterranean-inspired flavors, but you can use parsley or basil if you prefer.

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French Onion Dip Chicken & Rice Casserole

French Onion Dip Chicken & Rice Casserole
Credit: Greg Dupree
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This creamy French onion dip chicken and rice casserole topped with crispy potato chips is perfect for game day or whenever you want a comforting meal the whole family will love.

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Cheesy Ground Beef & Cauliflower Casserole

Cheesy Ground Beef & Cauliflower Casserole
Credit: Jason Donnelly
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Ground beef and cauliflower combine to create a hearty weeknight casserole that both kids and adults will love. Serve with tortilla chips and sour cream.

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Chicken Parmesan Casserole

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We took the best parts of chicken Parmesan--ooey-gooey cheese, crispy breadcrumbs and plenty of tomato sauce--and spun them into an easy family-friendly casserole. We simplified it by skipping the breading on the chicken and, instead, loaded the top of the casserole with cheese and breadcrumbs. Serve with a crisp green salad to complete the meal.

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Cheesy Ground Beef & Broccoli Casserole

cheesy ground beef broccoli casserole
Credit: Christine Ma
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This cheesy ground beef and broccoli casserole is comfort food the whole family can get behind. It's assembled and baked all in one skillet and finished in 30 minutes, making it the perfect weeknight meal.

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Chicken & Broccoli Casserole

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This one-pan chicken-and-broccoli recipe comes out of the oven all browned, cheesy and bubbling like a casserole, but is really prepared more like a skillet meal on the stovetop. Serve with a crunchy green salad.

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Cheesy Beef Enchilada Casserole

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This veggie-packed beef enchilada casserole is mild, so put out hot sauce and chopped jalapeños if you're feeding heat-seekers. The quick and easy dinner recipe makes extra cheese sauce--save it to make One-Pot Mac & Cheese with Cauliflower & Brussels Sprouts later in the week (see Associated Recipes) or serve it with steamed vegetables, such as broccoli, for an easy side dish.

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Cheesy Chicken & Cabbage Casserole

Cheesy Chicken & Cabbage Casserole
Credit: Diana Chistruga
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This cheesy chicken and cabbage casserole is creamy and briny with plenty of savory flavors thanks to sauerkraut and kielbasa. Gruyère (or Swiss) cheese adds a nutty flavor to the dish, while rye breadcrumbs on top give it a hint of caraway and a nice crunch.

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Spaghetti Squash Casserole

Spaghetti Squash Casserole
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Strands of tender squash replace pasta for a more flavorful version of spaghetti pie casserole. Not to mention, spaghetti squash is a low-carb alternative to pasta and saves more than 150 calories per serving compared to a traditional recipe. A sprinkling of nutty fontina cheese melts into a gooey topping.

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Chicken Cordon Bleu Casserole

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All the delicious flavors of your favorite chicken Cordon Bleu—salty ham, melty cheese, tangy mustard—with no tricky assembly required. This healthy comfort food recipe would be perfect for a potluck.

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Baked Eggs in Tomato Sauce with Kale

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You can make these three-ingredient tomato-simmered eggs with things you probably already have on hand in your freezer and pantry. To make these baked eggs more like eggs in purgatory, look for a spicy tomato sauce and don't forget some whole-wheat bread for dipping.

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Spinach & Artichoke Casserole with Chicken and Cauliflower Rice

Spinach & Artichoke Casserole with Chicken and Cauliflower
Credit: Photographer: Jen Causey, Prop Stylist: Julia Bayless, Food Stylist: Chelsea Zimmer
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This high-protein chicken casserole clocks in right around 400 calories to help you end your day feeling satisfied—not starved or overly full.

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Jalapeño Popper Casserole

Jalapeño Popper Casserole
Credit: Caitlin Bensel
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In this jalapeño popper casserole, tender, juicy bites of chicken are slathered in a creamy, slightly spicy sauce with a crunchy topping of panko breadcrumbs and crispy bacon. Enjoy this casserole over rice for dinner or serve it with chips as a game-day appetizer.

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Turkey-Vegetable Bake

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Need to use up leftover turkey from the holidays? Make this low fat casserole. It's made with brown rice and lots of vegetables.

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Chicken Spaghetti Casserole

Chicken Spaghetti Casserole
Credit: Photographer: Victor Protasio, Food Stylist Karen Rankin
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This chicken spaghetti casserole has a super-creamy sauce that coats pasta, chicken and a generous serving of veggies. Panko gives this family-friendly casserole a bit of crunch on top. Be sure to let it rest for 20 minutes after coming out of the oven. This allows the casserole to cool and also set up nicely before serving.

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Tamari-Ginger Meatball & Eggplant Casserole

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Eggplant soaks up the flavors of ginger, garlic and tamari in this Asian-inspired casserole recipe. A hot pepper in the topping adds a bit of heat, but opt for sweet if you prefer.

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Chicken Tamale Casserole

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In this Tex-Mex casserole inspired by chicken tamales, a saucy chicken filling with a soft polenta or grits topping is baked in a casserole dish. While it can't take the place of true tamales, it certainly makes for an easy and scrumptious weeknight dinner.

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Quinoa Lasagna

Quinoa Lasagna
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This healthy quinoa lasagna recipe has a layer of quinoa (rather than noodles) along with vegetables, cheese and herbs. Though it tastes like comfort food, don't worry, this quinoa lasagna recipe is not too heavy--you'll still have room for dessert. To save time, use your favorite jarred tomato sauce in this vegetarian lasagna. (Adapted from "Quinoa Revolution" by Patricia Green and Carolyn Hemming; Pintail Books, 2012.)

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Chicken-Spaghetti Squash Bake

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In this version of a chicken-and-broccoli casserole, spaghetti squash takes on a creamy texture when baked with cream of mushroom soup.

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Spinach & Tuna Noodle Casserole

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Homemade mushroom sauce kicks the can of soup out of the picture in this veggie-centric, healthy riff on a classic tuna-noodle casserole recipe. Serve with steamed green beans.

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    1 of 26 Tater Tot Casserole with Beef, Corn & Zucchini
    2 of 26 Cheesy Meatball Casserole
    3 of 26 Chicken Enchilada Skillet Casserole
    4 of 26 Cabbage Roll Casserole
    5 of 26 Philly Chicken Cheesesteak Casserole
    6 of 26 Tuna Casserole with Peas
    7 of 26 Eggplant & Chickpea Baked Pasta
    8 of 26 French Onion Dip Chicken & Rice Casserole
    9 of 26 Cheesy Ground Beef & Cauliflower Casserole
    10 of 26 Chicken Parmesan Casserole
    11 of 26 Cheesy Ground Beef & Broccoli Casserole
    12 of 26 Chicken & Broccoli Casserole
    13 of 26 Cheesy Beef Enchilada Casserole
    14 of 26 Cheesy Chicken & Cabbage Casserole
    15 of 26 Spaghetti Squash Casserole
    16 of 26 Chicken Cordon Bleu Casserole
    17 of 26 Baked Eggs in Tomato Sauce with Kale
    18 of 26 Spinach & Artichoke Casserole with Chicken and Cauliflower Rice
    19 of 26 Jalapeño Popper Casserole
    20 of 26 Turkey-Vegetable Bake
    21 of 26 Chicken Spaghetti Casserole
    22 of 26 Tamari-Ginger Meatball & Eggplant Casserole
    23 of 26 Chicken Tamale Casserole
    24 of 26 Quinoa Lasagna
    25 of 26 Chicken-Spaghetti Squash Bake
    26 of 26 Spinach & Tuna Noodle Casserole

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    26 High-Protein Casseroles That Are Perfect for Dinner
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