Avoid large meals late at night. According to the National Institutes of Health, late-night meals can cause indigestion that interferes with sleep. The same goes for alcohol. While a nightcap might help you relax before bed and initially fall asleep, drinking as little as two alcoholic drinks actually robs you of deep sleep and REM sleep, which means you wake up more frequently. Alcohol-related sleep disturbances are worse for women, say researchers at the University of Michigan.